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Keep an eye on Closely (one)istradefylline will boost the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism.diazepam will raise the degree or result of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.topiramate will reduce the extent or effect of diazepam by in